Реферат
Background: The novel corona virus is a high contagious disease, declared by World Health Organization (WHO) as a global pandemic in 2020 with profound impact on morbidity and mortality, assessment of outcomes in infected patients and knowledge of prediction of mortality and morbidity are important. We aimed to assess the clinical and laboratory findings in predicting COVID-19 severity and outcome in patients admitted to Suez Canal University Teaching Hospital. Methodology: This cross-sectional prospective study included 500 confirmed PCR COVID-19 infected patients, selected through random sampling. A structured checklist was used to collect patient data. Results: Mean age was 61.8 years, 56.2% were males, 74.8% had comorbidities. Lung involvement was evident in more than 75% on CT, 17.2% had leukopenia, 42.2% had lymphocytopenia between 5 – 10% and 93% of the patients had elevated neutrophil-lymphocyte ratio. 65.8% had elevated D-dimer, and elevated liver and kidney functions were found in 40.6% and 25% respectively. The mortality rate in studied population was 30.2% and it was significantly associated with old age, hypoxemia, having high involvement of the lungs on CT. Decreased WBC count, high D-dimer level and high NLR associated with severity and increased death rate of the disease. Conclusion: The study revealed many findings with impact on the patient's severity and outcome old age, laboratory findings, CT imaging and need to antiviral therapy the most predicting factors of the severity and prognosis of the patient. © 2020 The author (s). Published by Zagazig University.
Реферат
Background: During the COVID-19 pandemic, the pattern of medical services changed to minimize transmission to health care workers (HCWs) or hospitalized patients. Despite the care of COVID-19 patients in a special ward, new cases are accidentally discovered. This study aimed at determining the antibody seroprevalence among asymptomatic HCWs and the associated risks. Methods: The study involved 190 participants, including physicians, nurses, technicians, and administrative staff. All were inquired for sociodemographic, specialty, previous isolation, and previous infection, and their blood was tested for SARS-CoV2 antibody. Results: Of 190 HCWs;72,1% were females, the mean age was 32.6±7.9 years, 10.5% were smokers, and 15.8% reported co-morbid illness. SARS CoV2 antibodies were found in 68 (35.8%);being IgG, IgM and both IgM and IgG in 47 (69.1%), 10 (14.7%) and 11 (16.2%) participants respectively. The prevalence was higher (47.6%) among HCWs of the COVID unit, [OR=1.7 (95% CI: 0.69-4.3)] and HCWs with previous COVID-19, OR:1.61 (95% CI:0.88-2.94). The prevalence was significantly lower among smokers (p=0.049), OR:0.29 (95% CI:0.08-1.01), and significantly higher in HCWs who recalled cough (p=0.036) OR: 1.97 (95% CI: 1.05-3.69). The likelihood of antibody seropositivity increased in technicians [OR:2.02 (95% CI: 0.92-4.44)], followed by physicians [OR:1.7 (95% CI: 0.7-4.33)] while the odds ratio was low among nurses [OR:0.58 (95% CI: 0.32-1.07). Conclusion: A considerable proportion of antibody positive HCWs had evidence of past SARS CoV2. Provision of adequate personal protective equipment and periodic screening of HCWs are urgently needed to lessen the transmission within the health care settings. © 2020 The author (s).